The Root of Thought: Unlocking Glia¿the Brain Cell That Will Help Us Sharpen Our Wits, Heal Injury, and Treat Brain Disease

NEW YORK TIMES BESTSELLER

THIRTEEN EXTRAORDINARY ESSAYS SHED NEW LIGHT ON THE MYSTERIES OF THE UNIVERSE—AND ON ONE OF THE MOST BRILLIANT THINKERS OF OUR TIME.
 
In his phenomenal bestseller A Brief History of Time, Stephen Hawking literally transformed the way we think about physics, the universe, reality itself. In these thirteen essays and one remarkable extended interview, the man widely regarded as the most brilliant theoretical physicist since Einstein returns to reveal an amazing array of possibilities for understanding our universe.

Building on his earlier work, Hawking discusses imaginary time, how black holes can give birth to baby universes, and scientists’ efforts to find a complete unified theory that would predict everything in the universe. With his characteristic mastery of language, his sense of humor and commitment to plain speaking, Stephen Hawking invites us to know him better—and to share his passion for the voyage of intellect and imagination that has opened new ways to understanding the very nature of the cosmos.

After months of seeking treatment to no avail, in desperation Sarkin resorted to radical deep-brain surgery, which seemed to go well until during recovery his brain began to bleed and he suffered a major stroke. When he awoke, he was a different man. Before the stroke, he was a calm, disciplined chiropractor, a happily married husband and father of a newborn son. Now he was transformed into a volatile and wildly exuberant obsessive, seized by a manic desire to create art, devoting virtually all his waking hours to furiously drawing, painting, and writing poems and letters to himself, strangely detached from his wife and child, and unable to return to his normal working life. His sense of self had been shattered, his intellect intact but his way of being drastically altered. His art became a relentless quest for the right words and pictures to unlock the secrets of how to live this strange new life. And what was even stranger was that he remembered his former self.

In a beautifully crafted narrative, award-winning journalist and Pulitzer Prize finalist Amy Ellis Nutt interweaves Sarkin’s remarkable story with a fascinating tour of the history of and latest findings in neuroscience and evolution that illuminate how the brain produces, from its web of billions of neurons and chaos of liquid electrical pulses, the richness of human experience that makes us who we are. Nutt brings vividly to life pivotal moments of discovery in neuroscience, from the shocking “rebirth” of a young girl hanged in 1650 to the first autopsy of an autistic savant’s brain, and the extraordinary true stories of people whose personalities and cognitive abilities were dramatically altered by brain trauma, often in shocking ways.

Probing recent revelations about the workings of creativity in the brain and the role of art in the evolution of human intelligence, she reveals how Jon Sarkin’s obsessive need to create mirrors the earliest function of art in the brain. Introducing major findings about how our sense of self transcends the bounds of our own bodies, she explores how it is that the brain generates an individual “self” and how, if damage to our brains can so alter who we are, we can nonetheless be said to have a soul.

Long neglected as little more than cerebral packing material, glia (meaning “glue”) are now known to regulate the flow of information between neurons and to repair the brain and spinal cord after injury and stroke. But scientists are also discovering that diseased and damaged glia play a significant role in psychiatric illnesses such as schizophrenia and depression, and in neurodegenerative diseases such as Parkinson’s and Alzheimer’s. Diseased glia cause brain cancer and multiple sclerosis and are linked to infectious diseases such as HIV and prion disease (mad cow disease, for example) and to chronic pain. The more we learn about these cells that make up the “other” brain, the more important they seem to be.